Description

1,2-Difluoro-4-(Methylsulfonyl)Benzene is a high-purity fluorinated aromatic sulfone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine atoms and a methylsulfonyl group on a benzene ring, makes it a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoro and sulfone groups contribute to biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Material Precursor: Serves as a sophisticated intermediate in the manufacture of fluorinated compounds for electronic applications, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Polymer & Specialty Chemical Modifier: Incorporated into polymer chains or specialty chemicals to impart specific characteristics such as enhanced chemical resistance, thermal stability, or unique surface properties.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) due to the reactivity of the fluorine atoms and the sulfone group.
• Research & Development: A valuable reagent for academic and industrial research in medicinal chemistry, material science, and synthetic methodology development.

Basic Information

Product Name	1,2-Difluoro-4-(Methylsulfonyl)Benzene
CAS No.	424792-57-4
Molecular Formula	C7H6F2O2S
Molecular Weight	192.18 g/mol
Synonyms	4-(Methylsulfonyl)-1,2-difluorobenzene; 1,2-Difluoro-4-(methylsulfonyl)benzene; 3,4-Difluorophenyl Methyl Sulfone; 3,4-Difluorophenyl Methyl Sulphone; Methyl 3,4-Difluorophenyl Sulfone; Benzene, 1,2-difluoro-4-(methylsulfonyl)-; 424792-57-4
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-4-(Methylsulfonyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.