Description

Ruvbl1/2 Atpase-In-1 is a potent, cell-permeable, and selective small-molecule inhibitor of the RuvB-like AAA+ ATPases RUVBL1 and RUVBL2. This compound matters as it serves as a critical research tool for probing the biological functions of these essential chromatin remodeling and transcriptional co-activation complexes. Researchers in the fields of oncology, epigenetics, and molecular biology need it to investigate novel therapeutic targets, study complex cellular processes like DNA damage repair and oncogene signaling, and support drug discovery programs.

Application

• Biochemical Research: Used as a selective inhibitor to study the ATPase activity and biological functions of RUVBL1 and RUVBL2 complexes in vitro.
• Cancer Biology Studies: Employed in cellular assays to investigate the role of RUVBL1/2 in cancer cell proliferation, survival, and oncogenic pathways.
• Epigenetics & Chromatin Remodeling: A key tool for dissecting the involvement of the RUVBL1/2 complex in chromatin modification, transcriptional regulation, and histone exchange.
• Drug Discovery & Target Validation: Serves as a pharmacological probe for validating RUVBL1/2 as therapeutic targets in high-throughput screening and lead optimization campaigns.
• Signal Transduction Research: Applied to elucidate the crosstalk between RUVBL1/2-dependent pathways and other critical cellular signaling networks.
• Academic & Pharmaceutical R&D: Essential for basic research and pre-clinical development in institutions and companies focused on oncology and epigenetic therapies.

Basic Information

Product Name	Ruvbl1/2 Atpase-In-1
CAS No.	423128-55-6
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	RUVBL1/2 ATPase-IN-1; RUVBL Inhibitor; 423128-55-6; CID 16722845; RuvB-like 1/2 ATPase Inhibitor; 2-[(3,4-Dihydro-2H-chromen-6-yl)methyl]-3,4-dihydro-1H-isoquinoline-1,3(2H)-dione; CHEMBL3186660; BDBM50389375
EINECS	Contact for details

Quality Control

Our Ruvbl1/2 Atpase-In-1 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural verification, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support research requiring high-purity biochemical tools and can provide custom purity grades upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption. The product is stable under these conditions for at least two years from the date of receipt.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.