Description

Hesperadin CAS NO 422513-13-1 is a potent and selective small-molecule inhibitor of Aurora B kinase, a key regulator of cell division. This compound matters for researchers and developers in the life sciences as it provides a critical tool for studying mitotic progression, chromosome segregation, and cell cycle checkpoints. It is primarily needed by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on oncology, cell biology, and the development of novel anti-cancer therapeutics.

Application

• Biochemical Research: A selective tool compound for investigating the specific roles and signaling pathways of Aurora B kinase in vitro.
• Cell Biology Studies: Used to induce mitotic arrest and study chromosome alignment, cytokinesis, and spindle assembly checkpoint mechanisms.
• Oncology Research: Serves as a reference standard and pharmacological probe in target validation and preclinical studies for cancer drug discovery.
• Mechanistic Studies: Enables the exploration of Aurora B's function in histone H3 phosphorylation and its impact on epigenetic regulation.
• High-Content Screening (HCS): Utilized as a control in phenotypic screening assays to identify novel modulators of the mitotic machinery.
• Chemical Biology: Acts as a key reagent for understanding kinase inhibitor selectivity and structure-activity relationships (SAR).

Basic Information

Product Name	Hesperadin
CAS No.	422513-13-1
Molecular Formula	C₃₁H₄₃N₇O₃
Molecular Weight	561.72 g/mol
Synonyms	Hesperadin; Aurora B Kinase Inhibitor Hesperadin; N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide; 1-(5-tert-Butyl-2-oxazolylmethyl)-3-(5-carbamoyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl)urea (alternative representation); AURKB Inhibitor Hesperadin
EINECS	Contact for details

Quality Control

Our Hesperadin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.