Description

Z-Aevd-Fmk is a potent and selective fluoromethyl ketone-based caspase inhibitor, widely recognized in biochemical research for its role in apoptosis studies. This compound is critical for researchers investigating programmed cell death pathways and developing therapeutic strategies for related diseases. It is an essential tool for pharmaceutical R&D, academic laboratories, and biotechnology companies focused on oncology, neurobiology, and immunology.

Application

• Apoptosis Research: Used as a specific inhibitor to study caspase-mediated cell death pathways in various cell lines and model systems.
• Pharmaceutical Development: Serves as a key biochemical tool in the discovery and validation of novel therapeutic agents targeting apoptosis.
• Neurodegenerative Disease Studies: Applied in research models for Alzheimer's, Parkinson's, and other conditions involving dysregulated apoptosis.
• Immunology Research: Utilized to investigate the role of caspases in immune cell function and inflammatory responses.
• Biochemical Assay Standard: Acts as a reference compound in enzymatic assays to measure caspase activity and inhibitor potency.
• High-Throughput Screening (HTS): Employed in drug discovery campaigns to identify and characterize new apoptosis modulators.

Basic Information

Product Name	Z-Aevd-Fmk
CAS No.	419543-05-8
Molecular Formula	C24H32FN3O7
Molecular Weight	493.53 g/mol
Synonyms	Z-AEVD-FMK; Z-AEVD-Fluoromethyl Ketone; Benzyloxycarbonyl-Ala-Glu-Val-Asp-fluoromethyl ketone; Caspase-6 Inhibitor Z-AEVD-FMK; (Benzyloxycarbonyl)-L-alanyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methylpropyl)-2-oxopropyl]-L-valinamide; Z-Ala-Glu-Val-Asp-FMK; Apoptosis Inhibitor Z-AEVD-FMK
EINECS	Contact for details

Quality Control

Our Z-Aevd-Fmk is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.