Description

Pyr 41 is a potent and selective small molecule inhibitor of the ubiquitin-activating enzyme E1, a key component of the ubiquitin-proteasome system. This compound is a critical research tool for studying protein degradation pathways, cellular signaling, and the mechanisms underlying various diseases. It is primarily utilized by researchers and scientists in the fields of biochemistry, molecular biology, and oncology for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a specific inhibitor to study the ubiquitin-proteasome pathway and protein turnover mechanisms.
• Cancer Research: Investigated for its potential to induce apoptosis and inhibit proliferation in various cancer cell lines by blocking protein degradation.
• Signal Transduction Studies: Employed to dissect the role of ubiquitination in key signaling pathways such as NF-κB.
• Neurodegenerative Disease Research: Used in models of diseases like Alzheimer's and Parkinson's to understand the accumulation of misfolded proteins.
• Drug Discovery: Serves as a lead compound or pharmacological tool for validating E1 as a therapeutic target in high-throughput screening assays.
• Academic & Pharmaceutical R&D: Essential for basic research and preclinical studies aiming to develop novel therapies targeting protein homeostasis.

Basic Information

Product Name	Pyr 41
CAS No.	418805-02-4
Molecular Formula	C₁₇H₁₄N₄O₂
Molecular Weight	306.32 g/mol
Synonyms	4[4-(5-Nitro-2-furyl)-2-thiazolyl]pyridine; PYR-41; UBE1 Inhibitor PYR-41; Ubiquitin-activating enzyme E1 inhibitor; 4-[4-(5-Nitro-2-furanyl)-2-thiazolyl]pyridine; 4-(4-(5-Nitro-2-furyl)thiazol-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our Pyr 41 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.