Description

Cox-2 Inhibitor I CAS NO 416901-58-1 is a potent and selective small molecule inhibitor of the cyclooxygenase-2 (COX-2) enzyme. This compound is a critical research tool for investigating inflammatory pathways, pain mechanisms, and related disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Pharmacological Research: Used as a reference standard and active agent in studies of inflammation, pain, and fever.
• Drug Discovery & Development: Serves as a key biochemical tool for high-throughput screening (HTS) and validating novel COX-2 inhibitor candidates.
• Academic & Biomedical Research: Facilitates fundamental research into the role of COX-2 in cancer progression, neurodegenerative diseases, and other pathological conditions.
• Biochemical Assay Development: Employed in establishing and calibrating enzymatic assays to measure COX-2 activity and inhibition.
• In vitro & In vivo Studies: Applied in cell-based models and animal studies to elucidate the therapeutic and side-effect profiles of COX-2 inhibition.

Basic Information

Product Name	Cox-2 Inhibitor I
CAS No.	416901-58-1
Molecular Formula	C17H14F3N3O2S
Molecular Weight	381.37 g/mol
Synonyms	SC-236; 4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; Celecoxib derivative; COX-2 Inhibitor SC-236; Selective COX-2 Inhibitor I
EINECS	Contact for details

Quality Control

Our Cox-2 Inhibitor I is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The compound is for research use only in a laboratory setting.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.