Description

Hdm2 E3 Ligase Inhibitor CAS NO 414905-09-2 is a potent and selective small molecule compound designed to target and inhibit the Hdm2 E3 ubiquitin ligase, a key regulator of the p53 tumor suppressor pathway. This targeted inhibition is crucial for reactivating p53 function in cancer cells, making it a valuable tool for oncology research and therapeutic development. It is primarily used by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on cancer biology, drug discovery, and the development of novel anti-cancer agents.

Application

• Oncology Research & Drug Discovery: A critical tool for studying the p53-MDM2/MDMX interaction and screening for novel cancer therapeutics.
• Biochemical Assay Development: Used as a reference standard or active component in high-throughput screening (HTS) and enzymatic assays.
• Mechanism of Action Studies: Enables researchers to investigate apoptosis induction, cell cycle arrest, and tumor suppression mechanisms in vitro and in vivo.
• Preclinical Development: Serves as a lead compound or pharmacophore model for optimizing pharmacokinetics and efficacy in animal models.
• Combination Therapy Research: Explored in studies evaluating synergistic effects with chemotherapy, radiotherapy, or other targeted agents.
• Academic & Institutional Research: Supports fundamental research in molecular biology, protein degradation pathways, and cellular signaling.

Basic Information

Product Name	Hdm2 E3 Ligase Inhibitor
CAS No.	414905-09-2
Molecular Formula	C₂₀H₁₅ClF₃N₅O₂
Molecular Weight	449.81 g/mol
Synonyms	Nutlin-3; Nutlin 3; Nutlin-3a; RG7112 (Hydrochloride salt precursor); cis-4,5-Bis-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-3-oxide; MDM2 antagonist; HDM2 inhibitor; p53-MDM2 interaction inhibitor
EINECS	Contact for details

Quality Control

Our Hdm2 E3 Ligase Inhibitor is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via NMR and Mass Spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.