Description

2-Chloro-6-Fluorobenzylmagnesium Chloride is a highly reactive Grignard reagent, a critical organometallic building block for constructing complex molecular architectures. Its value lies in enabling the efficient formation of carbon-carbon bonds, specifically through nucleophilic addition to a wide range of electrophiles. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and scalable synthetic pathways for active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing a substituted benzyl moiety for therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the chloro-fluoro-benzyl group imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands and organometallic catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and polymers with tailored properties.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects and process development.
• Academic Research: A valuable reagent for methodological studies in organic and organometallic chemistry within university and institutional laboratories.

Basic Information

Item	Details
Product Name	2-Chloro-6-Fluorobenzylmagnesium Chloride
CAS No.	413589-35-2
Molecular Formula	C7H5Cl2FMg
Molecular Weight	203.32 g/mol
Synonyms	(2-Chloro-6-fluorophenyl)methylmagnesium chloride; 2-Chloro-6-fluorobenzylmagnesium chloride solution; 1-(Chloromagnesio)methyl-2-chloro-3-fluorobenzene; (2-Chloro-6-fluorobenzyl)magnesium chloride; Grignard reagent from 2-chloro-6-fluorobenzyl chloride; 2-Chloro-6-fluoro-α-tolylmagnesium chloride; Magnesium, chloro[(2-chloro-6-fluorophenyl)methyl]-
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-Fluorobenzylmagnesium Chloride is produced and handled under stringent quality protocols. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent composition, to ensure consistency and reliability for your synthetic applications. Certificates of Analysis (COA) documenting batch-specific results are available upon request, supporting compliance in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, easily oxidized, and reacts vigorously with protic solvents. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions to maintain stability. Keep away from moisture, strong acids, and any source of ignition. Use appropriate ventilation and chemical-resistant equipment when handling.

Specification

Item	Specification
Appearance	Colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Custom concentrations available)
Assay (Titration)	≥ 95% (as Grignard reagent)
Purity (GC/HPLC)	Contact for details
Solvent	Specified (Tetrahydrofuran, Diethyl ether, or other)
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.