Description

3-Chloro-4-Fluorophenylmagnesium Bromide is a highly reactive Grignard reagent, a critical organometallic intermediate for constructing complex organic molecules. Its value lies in enabling the efficient formation of carbon-carbon bonds, specifically introducing the versatile 3-chloro-4-fluorophenyl moiety into target structures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those containing halogenated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides that require the 3-chloro-4-fluorophenyl group for bioactivity.
• Material Science Research: Serves as a precursor for creating novel organic electronic materials, liquid crystals, and specialty polymers.
• Cross-Coupling Reactions: Acts as a nucleophile in palladium-catalyzed reactions like Kumada, Negishi, or Suzuki-Miyaura couplings to form biaryl structures.
• Nucleophilic Addition: Reacts with carbonyl compounds (aldehydes, ketones, esters) to produce secondary or tertiary alcohols with the incorporated aryl group.
• Custom Chemical Synthesis: Employed in contract research and manufacturing organizations (CROs/CMOs) for bespoke route development and scale-up projects.

Basic Information

Product Name	3-Chloro-4-Fluorophenylmagnesium Bromide
CAS No.	413589-34-1
Molecular Formula	C6H3ClFMgBr
Molecular Weight	233.74 g/mol (as bromide salt)
Synonyms	(3-Chloro-4-fluorophenyl)magnesium bromide; Magnesium, bromo(3-chloro-4-fluorophenyl)-; 3-Chloro-4-fluoro-phenylmagnesium bromide solution; 1-Chloro-2-fluoro-4-magnesiobromobenzene; Grignard Reagent (3-Cl-4-F-PhMgBr); 3-Cl-4-F-C6H3MgBr
EINECS	Contact for details

Quality Control

Every batch of our 3-Chloro-4-Fluorophenylmagnesium Bromide is manufactured and tested under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, concentration, and reactivity to ensure consistency and reliability for your critical synthesis steps. Our quality commitment supports compliance with cGMP and ICH guidelines where required for advanced intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. This material is highly volatile and hygroscopic (moisture-sensitive). It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions, or as specified on the label. Keep away from moisture, heat, and incompatible materials such as protic solvents, strong acids, and oxidizers. Use appropriate ventilation and safety measures in handling areas.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown
Concentration	Typically 0.5 M to 2.0 M in THF or Diethyl Ether
Assay (Titration)	≥ 95% (as C6H3ClFMgBr)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.