Description

Sirtinol CAS NO 410536-97-9 is a potent and selective inhibitor of the SIRT1 and SIRT2 class III histone deacetylases (HDACs). This compound matters as a critical research tool for investigating the role of sirtuins in cellular processes such as aging, metabolism, and stress response. It is primarily needed by researchers and developers in the life sciences, pharmaceutical R&D, and academic institutions for biochemical and cell-based studies.

Application

• Biochemical Research: Used as a specific inhibitor to study the enzymatic activity and biological functions of SIRT1 and SIRT2 deacetylases.
• Cell Biology Studies: Employed in cell culture models to investigate the role of sirtuins in pathways related to aging, calorie restriction, and genomic stability.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design of novel therapeutics targeting sirtuin-related diseases.
• Metabolic Disorder Research: Applied in studies exploring the connection between sirtuin activity, insulin signaling, and metabolic syndromes.
• Neurodegenerative Disease Models: Utilized in research focused on the potential role of sirtuins in conditions like Alzheimer's and Parkinson's disease.
• Oncology Research: Investigated for its effects on cancer cell proliferation and survival via modulation of sirtuin-mediated deacetylation.

Basic Information

Product Name	Sirtinol
CAS No.	410536-97-9
Molecular Formula	C14H14N2O3
Molecular Weight	258.27 g/mol
Synonyms	2-[(2-Hydroxynaphthalen-1-yl)methyleneamino]-N-(1-phenylethyl)acetamide; Sirtinol inhibitor; SIRT1/2 Inhibitor III; Sir2 Inhibitor; Sirtuin Inhibitor; Sirtinol (SIRT1/2 inhibitor); 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)acetamide
EINECS	Contact for details

Quality Control

Our Sirtinol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.