Description

5-Cyano-2-Methoxybenzenesulfonyl Chloride is a high-purity, versatile sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its reactive sulfonyl chloride group and strategically placed cyano and methoxy substituents make it an invaluable intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonamide moiety imparts biological activity.
• Functional Material Production: Building block for creating specialty polymers, dyes, and liquid crystals that require specific electronic or steric properties.
• Chemical Research & Development: A versatile reagent for introducing the sulfonyl group into complex molecular architectures in academic and industrial R&D settings.
• Peptide Modification: Employed in bioconjugation chemistry to modify amino acid side chains, such as lysine, for probe or linker attachment.

Basic Information

Product Name	5-Cyano-2-Methoxybenzenesulfonyl Chloride
CAS No.	409359-25-7
Molecular Formula	C8H6ClNO3S
Molecular Weight	231.66 g/mol
Synonyms	2-Methoxy-5-cyanobenzenesulfonyl chloride; 5-Cyano-2-methoxybenzenesulfonyl chloride; 2-Methoxy-5-cyanobenzene-1-sulfonyl chloride; 3-Cyano-4-methoxybenzenesulfonyl chloride; 4-Methoxy-3-cyanobenzenesulfonyl chloride; 5-Cyano-2-methoxy-phenylsulfonyl chloride; 5-Cyano-2-methoxybenzene-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Cyano-2-Methoxybenzenesulfonyl Chloride is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical processes. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.