Description

3-Buten-2-One, 4-(3-Fluoro-2-Hydroxyphenyl)- is a specialized fluorinated organic building block featuring a reactive α,β-unsaturated ketone (enone) moiety attached to a fluorinated phenolic ring. This unique structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for constructing novel active compounds, particularly where the introduction of fluorine atoms is desired to modulate biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in oncology, CNS, and anti-inflammatory research.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where fluorination enhances efficacy and environmental profile.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials.
• Chemical Synthesis: Utilized in organic chemistry research for Michael addition reactions, cycloadditions, and other transformations to create complex heterocycles.
• Ligand and Catalyst Development: The phenolic and ketone functionalities make it a useful precursor for creating chelating ligands and organocatalysts.

Basic Information

Product Name	3-Buten-2-One, 4-(3-Fluoro-2-Hydroxyphenyl)-
CAS No.	408504-74-5
Molecular Formula	C10H9FO2
Molecular Weight	180.18 g/mol
Synonyms	4-(3-Fluoro-2-hydroxyphenyl)-3-buten-2-one; 1-(3-Fluoro-2-hydroxyphenyl)-3-buten-2-one; 3-Buten-2-one, 4-(3-fluoro-2-hydroxyphenyl)-; 4-(3-Fluoro-2-hydroxy-phenyl)-but-3-en-2-one; 3-Fluoro-2-hydroxybenzalacetone; (E)-4-(3-Fluoro-2-hydroxyphenyl)but-3-en-2-one; 4-(3-Fluoro-2-hydroxyphenyl)but-3-en-2-one
EINECS	Contact for details

Quality Control

Our production of 3-Buten-2-One, 4-(3-Fluoro-2-Hydroxyphenyl)- adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques (HPLC, GC, NMR). We support cGMP and ISO 9001 compliant manufacturing for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.