Description

4-Trifluoromethylphenol is a versatile fluorinated aromatic compound, widely recognized for its unique combination of phenolic and trifluoromethyl functionalities. This structure makes it a critical building block in advanced chemical synthesis, offering enhanced lipophilicity, metabolic stability, and electronic properties to target molecules. It is essential for R&D and production in the pharmaceutical, agrochemical, and specialty materials industries, where it serves as a key intermediate for creating active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anti-inflammatory, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group improves biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a core component in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, enhancing electronic properties and device performance.
• Polymer & Resin Modifier: Incorporated into specialty polymers, epoxy resins, and coatings to impart improved chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, etherification, and as a precursor for more complex fluorinated compounds in fine chemical production.
• Dye & Pigment Industry: Acts as an intermediate in the synthesis of high-performance, light-fast dyes and pigments.

Basic Information

Product Name	4-Trifluoromethylphenol
CAS No.	402-45-9
Molecular Formula	C7H5F3O
Molecular Weight	162.11 g/mol
Synonyms	p-Trifluoromethylphenol; 4-Hydroxybenzotrifluoride; α,α,α-Trifluoro-p-cresol; 4-(Trifluoromethyl)phenol; 1-Hydroxy-4-(trifluoromethyl)benzene; Phenol, 4-(trifluoromethyl)-; NSC 406908
EINECS	206-936-9

Quality Control

Our 4-Trifluoromethylphenol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.