Description

2-Bromo-3,4,5,6-Tetrafluorophenol is a halogenated and fluorinated phenol derivative, serving as a versatile and high-value building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents, makes it a critical intermediate for introducing specific steric and electronic properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require precise fluorinated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to influence molecular polarity and alignment.
• Polymer & Material Science: Acts as a monomer or modifier in the synthesis of specialty polymers, including engineering plastics and coatings with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Electronics: Utilized in the research and development of organic semiconductors, OLED materials, and other electronic components where fluorination improves charge transport and device efficiency.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl structures.

Basic Information

Product Name	2-Bromo-3,4,5,6-Tetrafluorophenol
CAS No.	1998-62-5
Molecular Formula	C6HBrF4O
Molecular Weight	244.97 g/mol
Synonyms	2-Bromo-3,4,5,6-tetrafluorophenol; Phenol, 2-bromo-3,4,5,6-tetrafluoro-; 3,4,5,6-Tetrafluoro-2-bromophenol; 2-Bromotetrafluorophenol; NSC 403119; BTFPH; 2-Br-3,4,5,6-F4-PhOH
EINECS	Contact for details

Quality Control

Our 2-Bromo-3,4,5,6-Tetrafluorophenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	65 - 70 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.