Description

Methyl 5-Bromo-6-Fluoronicotinate is a high-purity, advanced pharmaceutical intermediate and versatile chemical building block. This compound is specifically designed for the synthesis of complex molecules, offering a critical halogenated pyridine scaffold for medicinal chemistry and agrochemical research. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce bromo and fluoro substituents into nicotinate-based structures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage halogenated heterocycles.
• Chemical Building Block: Serves as a versatile substrate for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and further functionalization in organic synthesis.
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and advanced organic electronic materials.
• Academic & Contract Research: A valuable reagent for university laboratories and CROs (Contract Research Organizations) exploring new chemical entities and reaction methodologies.

Basic Information

Product Name	Methyl 5-Bromo-6-Fluoronicotinate
CAS No.	405939-62-0
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	5-Bromo-6-fluoro-3-pyridinecarboxylic acid methyl ester; Methyl 5-bromo-6-fluoropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-bromo-6-fluoro-, methyl ester; 5-Bromo-6-fluoronicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-6-Fluoronicotinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC/MS for solvent residue analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	≤ 2.0% total
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.