Description

Gw 3965 Hydrochloride is a high-purity, non-steroidal synthetic agonist for the liver X receptor (LXR), specifically targeting the LXRβ isoform. This compound is of significant value for its role in modulating cholesterol metabolism and inflammatory pathways, making it a critical tool for pharmaceutical research and development. It is primarily needed by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in metabolic disease, atherosclerosis, and inflammation-related drug discovery programs. Our supply ensures consistent quality and reliable availability for your critical R&D and manufacturing processes.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel LXR-targeting therapeutics.
• Metabolic Disease Studies: Used as a potent research chemical to investigate pathways related to cholesterol homeostasis, reverse cholesterol transport, and atherosclerosis in preclinical models.
• Inflammation and Immunology Research: Employed to study the anti-inflammatory effects of LXR activation in various cellular and animal models of inflammatory diseases.
• Biochemical Assay Development: Serves as a critical control compound in high-throughput screening (HTS) assays designed to identify new LXR modulators.
• Academic Research: Utilized in university and institutional labs for fundamental research into nuclear receptor biology and signal transduction.
• GMP Manufacturing: Available in grades suitable for use as a starting material or intermediate in cGMP-compliant drug substance synthesis under appropriate quality agreements.

Basic Information

Product Name	Gw 3965 Hydrochloride
CAS No.	405911-17-3
Molecular Formula	C30H32ClF3N2O3 • HCl
Molecular Weight	605.95 g/mol
Synonyms	GW3965 HCl; GW-3965 hydrochloride; N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide hydrochloride; T0901317 analog; LXR agonist GW3965; LXRβ agonist; Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our Gw 3965 Hydrochloride is manufactured under strict quality control protocols to ensure it meets the high standards required for research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines and can provide material for use in regulated environments under appropriate quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.