Description

Chir-124 is a selective and potent small molecule inhibitor of Chk1 (Checkpoint kinase 1), a key regulator in the DNA damage response pathway. This compound is a critical research tool for investigating cell cycle control, DNA repair mechanisms, and the development of novel cancer therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology and molecular biology.

Application

• Biochemical Research: Used as a selective Chk1 kinase inhibitor to study DNA damage checkpoint signaling and cell cycle progression in vitro.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in the development of novel chemotherapeutic agents and combination therapies.
• Mechanistic Studies: Employed to elucidate the role of Chk1 in apoptosis, genomic stability, and cellular response to genotoxic stress.
• Synergistic Therapy Research: Investigated for its potential to sensitize cancer cells to DNA-damaging agents like radiation or chemotherapy.
• Cell Biology Assays: A key reagent in high-throughput screening and functional assays to identify and validate new drug targets.
• Reference Standard: Used for quality control, method development, and calibration in analytical laboratories.

Basic Information

Product Name	Chir-124
CAS No.	405168-58-3
Molecular Formula	C₂₀H₂₀ClN₅O₂
Molecular Weight	397.86 g/mol
Synonyms	Chir124; CHIR-124; 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-2-carboxamide; Chk1 Inhibitor II; Checkpoint Kinase 1 Inhibitor Chir-124; 2-Pyridinecarboxamide, 6-amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-2-carboxamide
EINECS	Contact for details

Quality Control

Our Chir-124 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.