Description

Ac-Lehd-Cmk is a specialized biochemical compound, also known as Ac-Leu-Glu-His-Asp-CHO, which functions as a potent and selective inhibitor of caspase-3 and related caspases. This compound is critical for researchers investigating apoptotic pathways and developing therapeutic strategies for diseases involving dysregulated cell death. It is primarily utilized by pharmaceutical R&D teams, academic biochemistry laboratories, and biotechnology companies focused on oncology, neurobiology, and inflammatory disease research.

Application

• Apoptosis Research: A key tool for selectively inhibiting caspase-3 activity in cell-based and biochemical assays to study programmed cell death mechanisms.
• Drug Discovery Screening: Used in high-throughput screening platforms to identify and validate novel compounds that modulate caspase pathways.
• Neurodegenerative Disease Models: Applied in research models for Alzheimer's, Parkinson's, and stroke to understand the role of caspases in neuronal cell death.
• Oncology Research: Employed to investigate the resistance of cancer cells to apoptosis and to test potential chemotherapeutic agents.
• Inflammation Studies: Useful for dissecting the inflammatory caspase cascade (caspase-1, -4, -5) in immune response studies.
• Biochemical Reagent: Serves as a reference standard and active inhibitor in enzymatic studies to determine caspase specificity and kinetics.

Basic Information

Product Name	Ac-Lehd-Cmk
CAS No.	403848-57-7
Molecular Formula	C24H38N6O9
Molecular Weight	554.60 g/mol
Synonyms	Ac-Leu-Glu-His-Asp-CHO; Ac-LEHD-CHO; Caspase-9 Inhibitor; Caspase-9 Inhibitor II; Ac-Leu-Glu-His-Asp-al; N-Acetyl-Leu-Glu-His-Asp-aldehyde; LEHDase Inhibitor; Apoptosis Inhibitor Ac-LEHD-CHO
EINECS	Contact for details

Quality Control

Every batch of Ac-Lehd-Cmk is manufactured under strict quality management protocols to ensure the highest standards of purity and consistency for research applications. Our products undergo rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water
Biological Activity (IC50 Caspase-9)	≤20 nM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.