Description

Dl-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3 is a stable isotope-labeled analog of the amino acid tyrosine, specifically deuterated at multiple positions. This high-purity compound is essential for use as an internal standard in quantitative mass spectrometry, ensuring analytical accuracy and reliability. It is primarily required by research institutions and pharmaceutical companies engaged in advanced metabolomics, proteomics, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS in quantitative bioanalysis of tyrosine and related metabolites.
• Tracer compound in metabolic pathway research and flux analysis studies.
• Critical reagent in proteomics for the development of stable isotope labeling by amino acids in cell culture (SILAC) methods.
• Use in pharmaceutical R&D for drug metabolism and pharmacokinetics (DMPK) studies.
• Biochemical research involving enzyme kinetics and mechanisms where isotopic labeling is required.
• Production of labeled peptides and proteins for structural biology and biomarker discovery.

Basic Information

Product Name	Dl-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3
CAS No.	402835-78-3
Molecular Formula	C9H5D7NO3
Molecular Weight	186.24 g/mol (approx.)
Synonyms	DL-Tyrosine-d7; (2,3,3-D3, 3,5-D2)-DL-Tyrosine; DL-4-Hydroxyphenylalanine-d7; DL-3-(4-Hydroxyphenyl)-2-aminopropanoic acid-d7; Tyrosine (ring-3,5-D2, alanine-2,3,3-D3, DL); Deuterated DL-Tyrosine; Stable Isotope-Labeled Tyrosine; Internal Standard Tyrosine-d7
EINECS	Contact for details

Quality Control

Our Dl-4-Hydroxyphenyl-D4-Alanine-2,3,3-D3 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and absence of critical impurities. We adhere to rigorous in-house specifications designed to meet the demands of advanced research and regulatory submission support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.