Description

Cositecan CAS NO 401905-67-7 is a potent synthetic camptothecin analog and topoisomerase I inhibitor developed for advanced oncological research and therapeutic applications. Its primary value lies in its enhanced stability and targeted mechanism of action, which are critical for developing next-generation chemotherapeutic agents. This compound is essential for pharmaceutical R&D laboratories, clinical research organizations, and academic institutions focused on oncology, particularly in the investigation of solid tumors and novel drug delivery systems.

Application

• Oncological Research & Drug Development: Serves as a key active pharmaceutical ingredient (API) and reference standard in the preclinical and clinical development of new cancer therapies.
• Biochemical Mechanism Studies: Used as a precise tool to study topoisomerase I inhibition, DNA damage response, and apoptosis pathways in cellular models.
• Pharmaceutical Formulation: Employed in the development and stability testing of injectable formulations and other dosage forms for clinical trials.
• Analytical Reference Standard: Provides a high-purity benchmark for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.
• Combinatorial Therapy Research: Investigated in studies exploring synergistic effects with other anticancer agents to overcome drug resistance.

Basic Information

Product Name	Cositecan
CAS No.	401905-67-7
Molecular Formula	C₂₄H₂₅N₃O₅
Molecular Weight	435.47 g/mol
Synonyms	7-(4-Methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin; CKD-602; Belotecan; Camptothecin analog CKD602; (S)-10,11-Methylenedioxy-20-camptothecin 7-(4-methyl-1-piperazinyl)methyl; 7-((4-Methylpiperazin-1-yl)methyl)-10,11-(methylenedioxy)-20(S)-camptothecin
EINECS	Contact for details

Quality Control

Our Cositecan is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development purposes. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.