Description

Glycyrrhetic Acid Impurity 3 (Glycyrrhetic Acid 3-o-β-Glucuronide) is a characterized impurity and metabolite of glycyrrhetic acid, a key bioactive constituent of licorice root. This high-purity reference standard is critical for analytical method development, validation, and quality control in pharmaceutical manufacturing to ensure product safety and efficacy. It is an essential material for researchers and quality assurance professionals in the pharmaceutical, nutraceutical, and herbal extract industries who require reliable standards for impurity profiling and pharmacokinetic studies.

Application

• Pharmaceutical Reference Standard: Used as a certified impurity standard for the quality control and regulatory compliance of glycyrrhetic acid and licorice-derived APIs (Active Pharmaceutical Ingredients).
• Analytical Method Development: Essential for developing and validating HPLC, UPLC, and LC-MS methods for the accurate quantification of impurities in drug substances and finished products.
• Metabolite Studies: Serves as a reference compound in pharmacokinetic and drug metabolism research to understand the biotransformation pathways of glycyrrhetic acid.
• Herbal Extract Standardization: Employed in the assay and impurity profiling of licorice root extracts to ensure batch-to-batch consistency and potency in nutraceutical formulations.
• Stability Testing: Used to identify and monitor degradation products in stability studies of drug products containing glycyrrhetic acid.

Basic Information

Product Name	Glycyrrhetic Acid Impurity 3 (Glycyrrhetic Acid 3-o-β-Glucuronide)
CAS No.	400870-85-1
Molecular Formula	C36H54O10
Molecular Weight	646.81 g/mol
Synonyms	Glycyrrhetinic Acid 3-O-β-D-Glucuronide; 3-O-β-Glucuronyl-glycyrrhetic Acid; 3β-[(β-D-Glucopyranosyluronic acid)oxy]-11-oxoolean-12-en-30-oic acid; Glycyrrhetic Acid Glucuronide; Enoxolone Glucuronide; Glycyrrhetate 3-O-Glucuronide; 18β-Glycyrrhetinic Acid 3-O-Glucuronide; GA-3G
EINECS	Contact for details

Quality Control

Our Glycyrrhetic Acid Impurity 3 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS analyses. We support compliance with ICH guidelines for impurity qualification, making this standard suitable for pharmaceutical R&D and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.