Description

4-Fluoro-4-Phenylpiperidine is a high-value fluorinated piperidine derivative, a crucial building block in modern synthetic organic chemistry. Its unique structure, featuring a fluorine atom at the 4-position of the piperidine ring, makes it an essential intermediate for constructing complex molecules with tailored pharmacological properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and receptor-targeted therapies.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Material Science: Investigated as a monomer or additive for creating specialty polymers with unique properties.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under GMP or ISO guidelines.

Basic Information

Product Name	4-Fluoro-4-Phenylpiperidine
CAS No.	400770-91-4
Molecular Formula	C11H14FN
Molecular Weight	179.24 g/mol
Synonyms	4-Fluoro-4-phenylpiperidine; 4-Phenyl-4-fluoropiperidine; 4-Fluoro-4-phenyl-piperidine; 4-Fluoro-4-phenylpiperidine hydrochloride (salt form); 4-Fluorophenyl-4-piperidine; 1-(4-Fluorophenyl)piperidin-4-ol (related precursor); 4-Fluoro-α-phenyl-4-piperidinemethanol (related derivative); α-Phenyl-4-fluoro-4-piperidinemethanol
EINECS	Contact for details

Quality Control

Our 4-Fluoro-4-Phenylpiperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production can adhere to ISO 9001 standards, and we support development projects requiring materials produced under GMP guidelines for preclinical and clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.