Description

Rg108 is a potent and selective small molecule inhibitor of DNA methyltransferases (DNMTs), a key class of epigenetic enzymes. This compound is crucial for researchers investigating the role of DNA methylation in gene expression, cellular differentiation, and disease pathogenesis. It is an essential biochemical tool for pharmaceutical R&D, academic research, and biotechnology applications focused on epigenetics, oncology, and neurological disorders.

Application

• Epigenetic Research: Used as a chemical probe to inhibit DNMT activity and study DNA demethylation processes in cellular and molecular biology.
• Oncology Studies: Investigated for its potential to reactivate tumor suppressor genes silenced by hypermethylation in cancer cell lines and models.
• Neuroscience Research: Applied in studies exploring the epigenetic mechanisms underlying neural development, plasticity, and neurodegenerative diseases.
• Stem Cell Biology: Utilized to modulate the epigenetic landscape to influence stem cell differentiation and reprogramming.
• Biochemical Assay Development: Serves as a reference standard and active control in high-throughput screening (HTS) for novel epigenetic modulators.
• Pharmacology: A key compound for proof-of-concept studies in developing new therapeutic strategies targeting epigenetic pathways.

Basic Information

Product Name	Rg108
CAS No.	48208-26-0
Molecular Formula	C12H13N3O2
Molecular Weight	231.25 g/mol
Synonyms	N-Phthalyl-L-tryptophan; RG-108; DNMT Inhibitor RG108; 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid; N-(1-Oxo-1,3-dihydro-2H-isoindol-2-yl)-L-tryptophan; L-Tryptophan, N-phthalyl-; Epigenetic modulator RG108
EINECS	Contact for details

Quality Control

Our Rg108 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A Certificate of Analysis (COA) detailing identity, purity, and assay results is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.