Description

Zopiclone n-Oxide CAS NO 43200-96-0 is a key pharmaceutical intermediate and metabolite of the sedative-hypnotic drug Zopiclone. This compound is of significant importance for research and development in the pharmaceutical industry, particularly in the study of drug metabolism, pharmacokinetics, and the synthesis of related active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in the development and quality control of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of Zopiclone and its structural analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods for pharmacokinetic and metabolism studies.
• Impurity Standard: Essential for the identification and quantification of process-related impurities in Zopiclone API manufacturing, ensuring product quality and regulatory compliance.
• Research Chemical: Employed in academic and industrial research to investigate the pharmacological profile and metabolic pathways of cyclopyrrolone derivatives.
• Quality Control (QC) Testing: Serves as a certified reference material (CRM) in HPLC, LC-MS, and other chromatographic assays for pharmaceutical quality assurance laboratories.

Basic Information

Item	Details
Product Name	Zopiclone n-Oxide
CAS No.	43200-96-0
Molecular Formula	C17H17ClN6O3
Molecular Weight	388.81 g/mol
Synonyms	6-(5-Chloro-2-pyridinyl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 4-oxide; Zopiclone N-Oxide; Zopiclone Impurity F (EP); Zopiclone Related Compound F (USP); Zopiclone Metabolite N-Oxide; 43200-96-0; 5H-Pyrrolo[3,4-b]pyrazin-5-one, 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-, 4-oxide
EINECS	Contact for details

Quality Control

Our Zopiclone n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles as per in-house specifications aligned with common pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.