Description

1-Chloro-4-(Difluoromethyl)Benzene, 97% is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic combination of chlorine and difluoromethyl substituents, which allows for precise modulation of electronic and steric properties in target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, contributing to improved performance in displays and lighting.
• Functional Material Research: Employed in R&D for creating novel polymers, ligands, and specialty chemicals with tailored properties.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures.

Basic Information

Product Name	1-Chloro-4-(Difluoromethyl)Benzene, 97%
CAS No.	43141-66-8
Molecular Formula	C7H5ClF2
Molecular Weight	162.56 g/mol
Synonyms	4-Chlorobenzyl Difluoride; p-Chloro-α,α-difluorotoluene; 1-Chloro-4-(difluoromethyl)benzene; 4-Chlorobenzylidene Difluoride; (4-Chlorophenyl)difluoromethane; Benzene, 1-chloro-4-(difluoromethyl)-; α,α-Difluoro-4-chlorotoluene
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-(Difluoromethyl)Benzene, 97% is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to verify identity, purity, and impurity profiles. A Certificate of Analysis (COA) documenting all critical specifications is provided with every shipment to ensure traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly sealed due to potential sensitivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.