Description

Prostaglandin H2 CAS NO 42935-17-1 is a critical intermediate in the arachidonic acid cascade, serving as the direct precursor to all major prostaglandins and thromboxanes. Its significance lies in its central role as a substrate for research into the biosynthesis and physiological effects of downstream prostanoids. This compound is essential for pharmaceutical R&D, biochemical studies, and the development of analytical standards for the life sciences industry.

Application

• Biochemical Research: Used as a key substrate to study the enzymatic activity and inhibition of prostaglandin synthases and isomerases.
• Pharmaceutical Development: Serves as a critical intermediate in research focused on inflammation, pain, fever, and blood clotting pathways for novel drug discovery.
• Analytical Standard: Employed as a high-purity reference standard in HPLC, LC-MS, and other analytical methods for the quantification of eicosanoids in biological samples.
• Enzyme Kinetics Studies: Essential for investigating the kinetics and mechanism of action of cyclooxygenase (COX) enzymes.
• Cell Signaling Research: Utilized in studies exploring the role of prostanoids in cellular communication and physiological regulation.
• Metabolic Pathway Analysis: A fundamental compound for mapping and understanding the complex arachidonic acid metabolic network.

Basic Information

Product Name	Prostaglandin H2
CAS No.	42935-17-1
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	PGH2; Prostaglandin H2; (5Z,13E)-(15S)-9α,11α-Epidioxy-15-hydroxyprosta-5,13-dien-1-oic acid; 9α,11α-Epidioxy-15(S)-hydroxyprosta-5Z,13E-dien-1-oic acid; 5Z,13E-(15S)-9α,11α-Epidioxy-15-hydroxyprosta-5,13-dien-1-oic acid; Cyclic Prostaglandin H2; Arachidonic acid metabolite
EINECS	Contact for details

Quality Control

Our Prostaglandin H2 is produced and handled under strict quality protocols to ensure high purity and stability for sensitive research applications. Each batch is characterized using advanced analytical techniques, including NMR and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and related substance profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Keep the container in a dry, well-ventilated area designated for laboratory chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.