Description

2-[15N]Amino-2-Deoxy-D-Glucose Hydrochloride is a stable isotope-labeled derivative of 2-amino-2-deoxy-D-glucose (2-DG), where the amino group is enriched with the 15N isotope. This compound is a critical biochemical tool for metabolic pathway tracing and quantitative analysis using techniques like mass spectrometry and NMR spectroscopy. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, metabolic research, and analytical chemistry.

Application

• Metabolic Tracer Studies: Used as a stable isotope-labeled internal standard for the precise quantification of 2-DG and its metabolites in complex biological samples via LC-MS or GC-MS.
• NMR Spectroscopy: Serves as a probe for investigating glucose metabolism and glycosylation pathways, leveraging the 15N label for enhanced spectral clarity and specificity.
• Pharmaceutical Research: Employed in the development and validation of analytical methods for drugs targeting glucose metabolism, such as potential oncology therapeutics.
• Biochemical Assay Development: Acts as a reference standard in enzyme activity assays related to hexosamine and amino sugar metabolism.
• Nutritional Science Research: Used in studies to track the cellular uptake and utilization of modified sugars under various physiological conditions.

Basic Information

Product Name	2-[15N]Amino-2-Deoxy-D-Glucose Hydrochloride
CAS No.	42927-60-6
Molecular Formula	C6H14[15N]O5•HCl
Molecular Weight	~217.64 g/mol
Synonyms	2-Amino-2-deoxy-D-glucose-2-15N hydrochloride; 2-DG-2-15N HCl; D-Glucosamine-2-15N hydrochloride; 2-[15N]Amino-2-deoxy-D-glucopyranose hydrochloride; 2-[15N]Amino-2-deoxy-D-glucose HCl; 2-Deoxy-2-(15N)amino-D-glucose hydrochloride; (2R,3S,4R,5R)-2-(15N)Amino-3,4,5-trihydroxyhexanal hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-[15N]Amino-2-Deoxy-D-Glucose Hydrochloride is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR for isotopic enrichment verification and HPLC for chemical purity assessment. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, purity (HPLC), isotopic enrichment (NMR), and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N)	≥ 98 atom %
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.