Description

2-Trifluoromethoxy Toluene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique trifluoromethoxy substituent imparts enhanced lipophilicity and metabolic stability, making it a critical intermediate for the development of novel active compounds. This product is essential for research and manufacturing in the pharmaceutical and agrochemical industries, where it is used to create molecules with improved efficacy and performance.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a fluorinated core structure in the synthesis of electronic chemicals for display and lighting technologies.
• Specialty Polymer Modifier: Incorporated into polymer chains to improve chemical resistance, thermal stability, and surface properties of high-performance materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce the valuable -OCF₃ moiety.
• Dye & Pigment Intermediate: Used in the synthesis of specialized fluorinated colorants with superior lightfastness and solubility properties.

Basic Information

Product Name	2-Trifluoromethoxy Toluene
CAS No.	42908-77-0
Molecular Formula	C₈H₇F₃O
Molecular Weight	176.14 g/mol
Synonyms	1-Methyl-2-(trifluoromethoxy)benzene; o-(Trifluoromethoxy)toluene; 2-Methylphenyl trifluoromethyl ether; α,α,α-Trifluoro-o-cresol methyl ether; 2-(Trifluoromethoxy)methylbenzene; o-Trifluoromethoxytoluene; Benzene, 1-methyl-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethoxy Toluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for cGMP intermediate applications and advanced R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is incompatible with strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.