Description

n-(2-Pyridinylmethylene)-L-Leu-L-Leu-Leu-Ome is a synthetic tripeptide derivative featuring a pyridinylmethylene moiety, designed for advanced biochemical and pharmaceutical research. This compound is valued for its role as a specialized building block or potential protease inhibitor scaffold in drug discovery programs. It is primarily utilized by research scientists and process development chemists in the pharmaceutical, biotechnology, and academic sectors for investigating peptide-based therapeutics and biochemical pathways.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel protease inhibitors and other therapeutic peptides.
• Biochemical Assay Development: Used as a substrate or inhibitor in enzymatic assays to study protease activity and mechanism of action.
• Medicinal Chemistry: Acts as a crucial building block for structure-activity relationship (SAR) studies to optimize peptide drug candidates for potency and selectivity.
• Academic Research: Employed in university and institutional labs for fundamental studies in peptide chemistry, enzymology, and molecular biology.
• Process Chemistry: Utilized in the scale-up and optimization of synthetic routes for complex peptide active pharmaceutical ingredients (APIs).

Basic Information

Product Name	n-(2-Pyridinylmethylene)-L-Leu-L-Leu-Leu-Ome
CAS No.	42547-80-8
Molecular Formula	C27H43N5O4
Molecular Weight	501.67 g/mol
Synonyms	N-[(E)-(Pyridin-2-yl)methylidene]-L-leucyl-L-leucyl-L-leucine methyl ester; (Pyridin-2-ylmethylene)leucylleucylleucine methyl ester; L-Leu-L-Leu-Leu-OMe, N-(2-pyridinylmethylene)-; Methyl N-[(E)-2-pyridinylmethylene]leucylleucylleucinate; Protease Inhibitor Peptide Derivative; Trileucine Methyl Ester Pyridinylmethylene Schiff Base
EINECS	Contact for details

Quality Control

Our n-(2-Pyridinylmethylene)-L-Leu-L-Leu-Leu-Ome is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.