Description

5-Carboxybupranolol is a key pharmaceutical intermediate and a derivative of the β-blocker bupranolol. This compound is valued for its role in the synthesis and research of cardiovascular active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in medicinal chemistry and drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of bupranolol and related β-adrenergic blocking agents.
• Medicinal Chemistry Research: Used as a reference standard or precursor in the development and structure-activity relationship (SAR) studies of new cardiovascular drugs.
• Metabolite Studies: Serves as a model compound or analytical standard for investigating the metabolic pathways of bupranolol.
• Fine Chemical Synthesis: Employed in custom synthesis and the production of specialized, high-value chemical entities for clinical trials.
• Analytical Standard: Used in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.

Basic Information

Product Name	5-Carboxybupranolol
CAS No.	42242-69-3
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	1-(tert-Butylamino)-3-[(5-carboxy-2-propyl-1H-indol-3-yl)oxy]propan-2-ol; Bupranolol Carboxylic Acid; 5-Carboxy Bupranolol; 3-[2-Hydroxy-3-[(1,1-dimethylethyl)amino]propoxy]-2-propyl-1H-indole-5-carboxylic Acid; 5-Carboxy-3-[2-hydroxy-3-(tert-butylamino)propoxy]-2-propylindole
EINECS	Contact for details

Quality Control

Our 5-Carboxybupranolol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.