Description

6-Fluoropyridoxamine 5'-Phosphate is a fluorinated derivative of pyridoxamine phosphate, a key coenzyme form of vitamin B6. This modification introduces a fluorine atom, which can significantly alter the compound's metabolic stability, binding affinity, and biological activity, making it a valuable tool for biochemical research and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the life sciences sector for enzyme inhibition studies, metabolic pathway analysis, and as a potential precursor in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Biochemical Research Reagent: Used as a substrate analog or inhibitor in enzymatic studies, particularly those involving vitamin B6-dependent enzymes like transaminases and decarboxylases.
• Pharmaceutical Intermediates: Serves as a critical building block in the research and development of new drug candidates, especially those targeting neurological or metabolic disorders.
• Metabolic Pathway Analysis: Employed in tracer studies to investigate the role of vitamin B6 derivatives in cellular metabolism due to the fluorine tag.
• Enzyme Mechanism Probes: The fluorine atom acts as a probe to study enzyme active sites and reaction mechanisms through techniques like 19F NMR spectroscopy.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	6-Fluoropyridoxamine 5'-Phosphate
CAS No.	42242-44-4
Molecular Formula	C8H12FN2O5P
Molecular Weight	266.17 g/mol
Synonyms	6-F-PMP; 6-Fluoropyridoxamine phosphate; 4-(Aminomethyl)-5-fluoro-2-methylpyridin-3-ol 3-phosphate; 5'-Phosphopyridoxamine, 6-fluoro-; 6-Fluoro-PMP; 6-Fluoropyridoxamine-P; (4-(Aminomethyl)-5-fluoro-2-methylpyridin-3-yl) dihydrogen phosphate
EINECS	Contact for details

Quality Control

Our 6-Fluoropyridoxamine 5'-Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.