Description

6-Fluoropyridoxal is a fluorinated derivative of pyridoxal, a key form of Vitamin B6, distinguished by the strategic introduction of a fluorine atom at the 6-position of the pyridine ring. This specific modification is crucial for enhancing metabolic stability and altering binding affinity in biochemical systems, making it a valuable synthetic intermediate. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of enzyme inhibitors, diagnostic agents, and novel therapeutic compounds. The compound's unique structure serves as a critical building block in medicinal chemistry and biochemical research.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of fluorinated analogs of vitamin B6 and related coenzymes for drug discovery.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving pyridoxal phosphate (PLP)-dependent enzymes like transaminases and decarboxylases.
• Probe Development: Employed in the design of molecular probes and diagnostic tools to study vitamin B6 metabolism and transport mechanisms.
• Medicinal Chemistry: Acts as a versatile building block for creating novel compounds with potential therapeutic applications in neurology and metabolism.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	6-Fluoropyridoxal
CAS No.	42242-42-2
Molecular Formula	C8H8FNO3
Molecular Weight	185.15 g/mol
Synonyms	6-Fluoropyridoxal; 3-Hydroxy-5-(hydroxymethyl)-2-methyl-4-fluoropyridine-4-carboxaldehyde; 4-Pyridinecarboxaldehyde, 3-hydroxy-5-(hydroxymethyl)-2-methyl-6-fluoro-; 6-Fluoro-3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde; Fluoropyridoxal; Vitamin B6 Fluorinated Derivative
EINECS	Contact for details

Quality Control

Our 6-Fluoropyridoxal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents. We support compliance with various pharmacopeial and internal specifications tailored to customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.