Description

2-Difluoromethoxytoluene is a specialized fluorinated aromatic ether compound, identified by CAS NO 42173-52-4. This chemical serves as a valuable advanced intermediate in the synthesis of complex molecules, particularly within the pharmaceutical and agrochemical sectors. It is primarily sought by R&D chemists and process development teams for constructing active ingredients and functional materials that require the unique properties of fluorine substitution.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the production of fluorinated components for electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and weatherability.
• Organic Synthesis Reagent: Acts as a versatile reagent in cross-coupling reactions and as a protecting group in multi-step synthetic pathways in fine chemical production.

Basic Information

Product Name	2-Difluoromethoxytoluene
CAS No.	42173-52-4
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	1-Methyl-2-(difluoromethoxy)benzene; o-(Difluoromethoxy)toluene; 2-Methyl(difluoromethoxy)benzene; Benzene, 1-methyl-2-(difluoromethoxy)-; Toluene, o-difluoromethoxy-; Difluoromethyl 2-methylphenyl ether; 2-(Difluoromethoxy)methylbenzene
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxytoluene is produced under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.