Description

2-Bromo-5-Fluoropyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its molecular structure, featuring both bromine and fluorine substituents, makes it an invaluable intermediate for introducing functional complexity into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients, novel ligands, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluoropyridine core.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands used in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and organometallic catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and functional polymers.
• Chemical Biology & Proteomics: Useful as a tagging or labeling reagent in probe development for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A fundamental substrate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	2-Bromo-5-Fluoropyridine
CAS No.	41404-58-4
Molecular Formula	C5H3BrFN
Molecular Weight	175.99 g/mol
Synonyms	5-Fluoro-2-bromopyridine; 2-Bromo-5-fluoropyridine; 5-Fluoropyridin-2-yl bromide; 2-Bromo-5-fluoro-pyridine; 5-Fluoro-2-pyridyl bromide; 2-Pyridyl bromide, 5-fluoro-; 41404-58-4 (CAS)
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.