Description

8-Epi-Cyanocobalamin is a structural analog of Vitamin B12 (Cyanocobalamin), distinguished by the epimerization at the C-8 position of the corrin ring. This specific stereochemistry makes it a valuable reference standard and a critical intermediate in pharmaceutical research and analytical method development. It is primarily utilized by research institutions, pharmaceutical manufacturers, and quality control laboratories engaged in the synthesis, analysis, and study of cobalamin derivatives and related biological processes.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification, purity assessment, and quantification of Vitamin B12 and its analogs in HPLC, LC-MS, and other analytical methods.
• Biochemical Research: Used as a tool compound to study the structure-activity relationships, metabolic pathways, and biological functions of cobalamins.
• Method Development & Validation: Critical for developing and validating analytical procedures in pharmacopeial (USP, EP) compliance testing for cyanocobalamin APIs and finished dosage forms.
• Impurity Profiling: Employed to identify and quantify process-related impurities or degradation products in cyanocobalamin manufacturing.
• Nutritional Science Studies: Applied in research investigating the comparative bioavailability and metabolism of different cobalamin forms.

Basic Information

Product Name	8-Epi-Cyanocobalamin
CAS No.	41325-63-7
Molecular Formula	C₆₃H₈₈CoN₁₄O₁₄P
Molecular Weight	1355.37 g/mol
Synonyms	8-Epicyanocobalamin; Vitamin B12 8-epimer; (8R)-Cyanocobalamin; 8-Epi-vitamin B12; Coα-[α-(5,6-Dimethylbenzimidazolyl)]-Coβ-cyanocobamide 8-epimer; 8-Epi-B12; 8-Epicyanocobalamin (Vetranal); Cob(II)alamin 8-epimer cyanide complex
EINECS	Contact for details

Quality Control

Our 8-Epi-Cyanocobalamin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, spectroscopic identification (UV-Vis, IR), and residual solvent analysis, to ensure it meets the stringent requirements for use as a reference material. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container sealed in a dry, cool environment to maintain stability.

Specification

Item	Specification
Appearance	Dark red crystalline powder or solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (UV-Vis)	Spectrum conforms to reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 8.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.