Description

Methyl-D3-Magnesium Iodide is a deuterated Grignard reagent, a versatile organometallic compound where three hydrogen atoms in the methyl group are replaced by deuterium. This isotopic labeling makes it an essential tool for mechanistic studies, reaction pathway elucidation, and the synthesis of deuterated compounds in advanced research and development. It is primarily used by scientists and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise isotopic tracing and the development of novel active ingredients.

Application

• Deuterium-Labeled Pharmaceutical Synthesis: A key building block for incorporating stable deuterium isotopes into drug candidates to potentially improve metabolic stability, pharmacokinetics, and bioavailability.
• Mechanistic Organic Chemistry Research: Used as a probe in kinetic isotope effect (KIE) studies to investigate reaction mechanisms and transition states.
• Agrochemical Development: Synthesis of deuterated analogs of pesticides and herbicides for environmental fate studies and product development.
• NMR Spectroscopy & Analytical Standards: Preparation of internal standards and reference materials for quantitative NMR and mass spectrometry analysis.
• Material Science Research: Precursor for the synthesis of deuterated polymers or organic electronic materials for specialized research applications.
• Catalysis Studies: Employed in organometallic catalysis research to understand the role of specific hydrogen/deuterium atoms in catalytic cycles.

Basic Information

Product Name	Methyl-D3-Magnesium Iodide
CAS No.	41251-37-0
Molecular Formula	CD3MgI
Molecular Weight	182.26 g/mol
Synonyms	Magnesium, iodomethyl-d3-; Deuterated Methylmagnesium Iodide; (Methyl-d3)magnesium iodide; Methyl-d3-magnesium iodide solution; CD3MgI; Trideuteriomethylmagnesium iodide; Perdeuterated Methylmagnesium Iodide; Grignard Reagent-d3
EINECS	Contact for details

Quality Control

Our Methyl-D3-Magnesium Iodide is produced under stringent conditions to ensure high isotopic purity and chemical consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as concentration (typically in common solvents like diethyl ether or THF), isotopic enrichment (D atom %), and assay by titration. We adhere to rigorous internal quality standards to meet the precise requirements of research and process development. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile and moisture-sensitive nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. For solutions, recommended storage temperature is typically 2-8°C or as specified on the label. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Colorless to light brown or gray solution
Concentration	Typically 1.0M in diethyl ether or THF (other solvents available)
Isotopic Purity (D atom %)	≥ 98% (Contact for higher grades)
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.