Description

Alanine Chloromethyl Ketone is a specialized biochemical building block and a key intermediate in organic synthesis. This compound is valued for its reactive chloromethyl ketone functional group, which makes it a crucial precursor for the development of protease inhibitors and other pharmacologically active molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of protease inhibitors, particularly those targeting serine proteases.
• Biochemical Research: Used as an active site-directed irreversible inhibitor for studying enzyme mechanisms and kinetics.
• Peptide Mimetic Synthesis: Serves as a key precursor for creating peptide analogs and mimetics with enhanced stability or activity.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and the development of novel therapeutic agents.
• Protease Probe Development: Utilized to create affinity labels and activity-based probes for diagnostic and research applications.
• Fine Chemical Synthesis: Acts as a versatile alkylating agent in multi-step synthetic routes for complex organic molecules.

Basic Information

Product Name	Alanine Chloromethyl Ketone
CAS No.	41036-44-6
Molecular Formula	C5H8ClNO2
Molecular Weight	149.57 g/mol
Synonyms	L-Alanine Chloromethyl Ketone; N-(Chloroacetyl)-L-alanine; (S)-2-Amino-4-chloro-3-oxobutanoic Acid; Alanine Chloromethyl Ketone Hydrochloride (common salt form); ACK; Chloroacetyl-L-alanine; Protease Inhibitor Precursor; 41036-44-6
EINECS	Contact for details

Quality Control

Our Alanine Chloromethyl Ketone is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.