Description

Benzyloxycarbonylalanine Chloromethyl Ketone is a specialized peptide synthesis reagent designed for the irreversible inhibition of serine proteases. This compound matters for researchers and manufacturers requiring precise control over enzymatic activity in biochemical pathways. It is primarily needed by pharmaceutical R&D teams, academic biochemistry laboratories, and fine chemical producers developing protease-targeted therapeutics and diagnostic tools.

Application

• Protease Inhibitor Synthesis: A key building block for creating irreversible active-site directed inhibitors of serine proteases like chymotrypsin, elastase, and cathepsin G.
• Pharmaceutical Intermediate: Used in the research and development of novel therapeutic agents targeting inflammatory diseases, coagulation disorders, and certain cancers.
• Biochemical Research: Employed in enzymology studies to investigate protease structure, function, and mechanism of action.
• Peptide Chemistry: Serves as an acylating agent in the synthesis of complex peptide derivatives and affinity labels.
• Diagnostic Reagent Production: Utilized in the manufacture of specific enzyme substrates and inhibitors for clinical diagnostic assays.

Basic Information

Product Name	Benzyloxycarbonylalanine Chloromethyl Ketone
CAS No.	41036-43-5
Molecular Formula	C12H14ClNO4
Molecular Weight	271.70 g/mol
Synonyms	Z-Ala-CH2Cl; Cbz-Ala-CH2Cl; N-Carbobenzoxy-L-alanine chloromethyl ketone; Z-L-Alanine chloromethyl ketone; Benzyloxycarbonyl-L-alanine chloromethyl ketone; (S)-1-Chloro-3-((((benzyloxy)carbonyl)amino)propan-2-one; Protease Inhibitor Z-Ala-CH2Cl; Chymotrypsin Inhibitor
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonylalanine Chloromethyl Ketone is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.