Description

Surugatoxin CAS NO 40957-92-4 is a potent, naturally occurring neurotoxin originally isolated from the Japanese ivory mollusk, *Babylonia japonica*. This compound is of significant interest in neuroscience research due to its highly specific antagonistic action on nicotinic acetylcholine receptors. It serves as a critical research tool for studying receptor subtypes, synaptic transmission, and neurological pathways. Key users include pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuropharmacology and toxin-based probe development.

Application

• Neuroscience Research: Used as a selective probe to study the function and distribution of specific subtypes of neuronal nicotinic acetylcholine receptors (nAChRs).
• Pharmacological Studies: Employed in receptor binding assays and electrophysiological experiments to characterize ligand-receptor interactions and signal transduction mechanisms.
• Toxicology Research: Serves as a reference standard in studies investigating the mode of action of marine neurotoxins and their physiological effects.
• Drug Discovery: Acts as a molecular tool for screening and validating new compounds targeting the cholinergic system for conditions like pain, addiction, and neurodegenerative diseases.
• Biochemical Tool: Utilized in the purification and isolation of receptor proteins and in the development of diagnostic assays.

Basic Information

Product Name	Surugatoxin
CAS No.	40957-92-4
Molecular Formula	C₂₇H₃₃N₅O₈
Molecular Weight	555.58 g/mol
Synonyms	Surugatoxin; SNX; Babylonia japonica toxin; Ivory shell toxin; 5-(2-Hydroxy-2-oxoethyl)-2,3-dihydro-1H-pyrrolizine-7-carboxylic acid (6aS,7R,9R,9aR)-9-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6,8,9a-hexahydro-1H-pyrrolo[1,2-a]azepin-7-yl ester; (6aS,7R,9R,9aR)-9-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy-2,3,5,6,8,9a-hexahydro-1H-pyrrolo[1,2-a]azepin-7-yl 5-(2-hydroxy-2-oxoethyl)-2,3-dihydro-1H-pyrrolizine-7-carboxylate
EINECS	Contact for details

Quality Control

Our Surugatoxin is produced and handled under strict quality protocols to ensure the consistency and reliability required for sensitive research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and structural confirmation via NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, which includes batch-specific data on purity, identity, and impurities. Our quality system is designed to meet the rigorous standards of pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.