Description

(-)-Bicucullinemethiodide CAS NO 40709-69-1 is a high-purity, quaternary ammonium salt derivative of the natural alkaloid bicuculline, widely recognized as a potent and selective antagonist of GABAA receptors. This compound is critical for neuroscience and pharmacological research, enabling the study of inhibitory neurotransmission, receptor subtype specificity, and neurological disorders. It is an essential tool for research institutions, pharmaceutical R&D departments, and diagnostic laboratories focused on neuropharmacology, neurochemistry, and the development of central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: A fundamental tool for in vitro and ex vivo studies to block GABAA receptor-mediated inhibitory postsynaptic currents (IPSCs).
• Pharmacological Screening: Used as a reference standard in high-throughput screening assays to identify novel GABAergic modulators or anticonvulsant drugs.
• Electrophysiology: Essential for patch-clamp experiments to investigate the function and pharmacology of GABAA receptor channels in neuronal cultures and brain slices.
• Biochemical Assays: Employed in receptor binding studies (e.g., competitive displacement assays) to characterize receptor affinity and density.
• Disease Model Studies: Applied in research models of epilepsy, anxiety, and sleep disorders to understand the role of GABAergic inhibition.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting advanced studies in neurobiology and cellular signaling.

Basic Information

Product Name	(-)-Bicucullinemethiodide
CAS No.	40709-69-1
Molecular Formula	C21H20NO6•CH3I
Molecular Weight	525.29 g/mol
Synonyms	(-)-Bicuculline Methiodide; Bicuculline Methiodide; (S)-(-)-Bicuculline Methiodide; NSC 224994; 1(S),9(R)-Bicuculline Methiodide; (1S,9R)-Bicuculline Methiodide; GABAA Receptor Antagonist (Bicuculline Methiodide)
EINECS	Contact for details

Quality Control

Our (-)-Bicucullinemethiodide is manufactured under strict quality protocols to ensure high chemical and isomeric purity suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous in-house standards, and our quality systems support traceability and batch-to-batch consistency for reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Specific Rotation	-140° to -150° (c=1 in methanol)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.