Description

2,3,5,6-Tetrafluoro-4-Methoxybenzenesulfonyl Chloride is a high-value, multi-fluorinated sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a versatile sulfonylation reagent, introducing the highly stable and lipophilic tetrafluoro-methoxybenzenesulfonyl group into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and functional materials where enhanced metabolic stability and bioavailability are required.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), including protease inhibitors, kinase inhibitors, and other small molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved pesticidal activity and environmental persistence.
• Functional Material Precursor: Serves as a monomer or modifying agent in the creation of specialty polymers, liquid crystals, and electronic materials with specific surface or electronic properties.
• Chemical Biology & Proteomics: Employed as a labeling or cross-linking reagent for modifying proteins, peptides, and other biomolecules to study structure-function relationships.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of high-performance, light-fast dyes and pigments for specialized applications.
• Research & Development: A vital tool in medicinal chemistry and process chemistry for exploring new chemical entities and optimizing synthetic routes.

Basic Information

Product Name	2,3,5,6-Tetrafluoro-4-Methoxybenzenesulfonyl Chloride
CAS No.	40586-69-4
Molecular Formula	C7H3ClF4O3S
Molecular Weight	278.61 g/mol
Synonyms	4-Methoxy-2,3,5,6-tetrafluorobenzenesulfonyl chloride; Pentafluoromethoxybenzenesulfonyl chloride (common misnomer); 2,3,5,6-Tetrafluoro-4-methoxy-1-benzenesulfonyl chloride; Tetrafluoromethoxybenzenesulfonyl chloride; 4-Methoxy-2,3,5,6-tetrafluorophenylsulfonyl chloride; TFMBSC (abbreviation); 1-(Chlorosulfonyl)-2,3,5,6-tetrafluoro-4-methoxybenzene
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetrafluoro-4-Methoxybenzenesulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, typically ≥97% (by HPLC). Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced material supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.