Description

Acetyl-Seco-Hemicholinium-3 is a specialized hemicholinium derivative, a class of compounds known for their potent choline uptake inhibition. This compound is a critical research-grade biochemical tool for investigating cholinergic neurotransmission and related neurological pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, neuropharmacology, and the development of novel therapeutic agents.

Application

• Neuroscience Research: As a selective inhibitor of high-affinity choline uptake (HACU), it is a fundamental tool for studying the synthesis and regulation of acetylcholine in presynaptic nerve terminals.
• Pharmacological Studies: Used in in vitro and ex vivo assays to model cholinergic dysfunction and to evaluate the mechanisms of potential neuroprotective or cognitive-enhancing drugs.
• Biochemical Pathway Analysis: Employed to probe the cholinergic system's role in memory, learning, and neuromuscular function, aiding in the understanding of related disorders.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis and bioanalytical testing.
• Preclinical Drug Discovery: A key compound in target validation and screening campaigns for diseases like Alzheimer's, myasthenia gravis, and other conditions involving cholinergic signaling.

Basic Information

Product Name	Acetyl-Seco-Hemicholinium-3
CAS No.	40374-51-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Acetylsecohemicholinium-3; ASHC-3; 1,1'-[1,10-Decanediylbis(iminocarbonyl)]bis[N,N,N-trimethyl-2-aminoethanol] Diiodide; Hemicholinium-3, Acetylseco-; N,N,N-Trimethyl-2-[(10-[[2-(trimethylammonio)ethoxy]carbonylamino]decanoyl)amino]ethanaminium Diiodide
EINECS	Contact for details

Quality Control

Every batch of Acetyl-Seco-Hemicholinium-3 is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data (including HPLC purity, NMR, and MS confirmation) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.