Description

4-Nitrothiophene-2-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative, a critical building block in advanced organic synthesis. Its primary value lies in its role as a versatile electrophilic reagent for introducing the 4-nitrothiophene-2-sulfonyl moiety, enabling the development of novel compounds with specific functionalities. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry research targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the development of advanced pesticides, herbicides, and fungicides, contributing to the creation of more effective crop protection solutions.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced materials with tailored electronic or chemical properties.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes for studying enzyme function and biological pathways.
• Dye and Pigment Intermediate: Acts as a reactive intermediate in the synthesis of specialized dyes and pigments for high-performance applications.
• Cross-coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions for constructing complex heterocyclic systems.

Basic Information

Product Name	4-Nitrothiophene-2-Sulfonyl Chloride
CAS No.	40358-04-1
Molecular Formula	C4H2ClNO4S2
Molecular Weight	227.65 g/mol
Synonyms	2-Thiophenesulfonyl chloride, 4-nitro-; 4-Nitro-2-thiophenesulfonyl chloride; 4-Nitrothiophene-2-sulphonyl chloride; 4-Nitro-2-thienylsulfonyl chloride; 4-Nitrothienyl-2-sulfonyl chloride; 4-Nitro-2-thiophenesulfonic acid chloride; 2-Thienylsulfonyl chloride, 4-nitro-
EINECS	Contact for details

Quality Control

Our 4-Nitrothiophene-2-Sulfonyl Chloride is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.