Description

4-Bromo-2-Fluoropyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its unique reactivity, where the bromine and fluorine substituents offer orthogonal sites for selective functionalization via cross-coupling and nucleophilic substitution reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized nitrogen-containing ligands used in homogeneous catalysis.
• Material Science Research: Employed in the creation of functionalized organic molecules for organic light-emitting diodes (OLEDs) and electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl and other complex structures.
• Nucleophilic Aromatic Substitution: The fluorine atom can be selectively displaced by various nucleophiles, enabling efficient diversification of the pyridine core.

Basic Information

Product Name	4-Bromo-2-Fluoropyridine
CAS No.	40247-45-8
Molecular Formula	C5H3BrFN
Molecular Weight	175.99 g/mol
Synonyms	2-Fluoro-4-bromopyridine; 4-Bromo-2-fluoropyridine; 2-Fluoro-4-bromo-pyridine; Pyridine, 4-bromo-2-fluoro-; 4-Bromo-2-fluoro-pyridine; 40247-45-8; 4-Br-2-F-Py
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring cGMP and ISO standards for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.