Description

4-Bromo-3-Fluorobenzotrifluoride is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and halogen substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediates: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine motif enhances bioactivity.
• Material Science Precursor: Serves as a monomer or building block for specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and introducing the trifluoromethyl group into molecular scaffolds.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of specialized fluorinated dyes and pigments with unique properties.

Basic Information

Product Name	4-Bromo-3-Fluorobenzotrifluoride
CAS No.	40161-54-4
Molecular Formula	C7H3BrF4
Molecular Weight	242.99 g/mol
Synonyms	1-Bromo-2-fluoro-4-(trifluoromethyl)benzene; 4-Bromo-3-fluoro-α,α,α-trifluorotoluene; 2-Fluoro-4-(trifluoromethyl)bromobenzene; 4-Bromo-3-fluoro-α,α,α-trifluoromethylbenzene; 4-Bromo-3-fluorobenzyltrifluoride; (4-Bromo-3-fluorophenyl)trifluoromethane
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.