Description

Strophanthidin 3-Bromoacetate is a chemically modified cardiac glycoside derivative, specifically a bromoacetylated analog of strophanthidin. This compound is of significant value in pharmaceutical research and development as a key intermediate for synthesizing novel cardioactive agents and as a biochemical tool for studying sodium-potassium ATPase (Na+/K+-ATPase) inhibition. It is primarily needed by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in cardiovascular drug discovery, biochemical mechanism studies, and the production of specialized reference standards.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel cardiac glycoside derivatives and potential therapeutic agents targeting heart failure and arrhythmias.
• Biochemical Research: Used as a potent, site-specific probe to study the structure, function, and inhibition mechanisms of the Na+/K+-ATPase enzyme complex.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop new compounds with optimized efficacy and reduced toxicity profiles.
• Academic Research: Utilized in university and institutional labs for fundamental studies on ion transport, cell signaling, and cardiac physiology.

Basic Information

Product Name	Strophanthidin 3-Bromoacetate
CAS No.	4956-18-7
Molecular Formula	C26H35BrO7
Molecular Weight	539.46 g/mol
Synonyms	3-Bromoacetylstrophanthidin; Strophanthidin 3-bromoacetate; 3β-[(Bromoacetyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide; 5β,14β-Dihydroxy-3β-[(bromoacetyl)oxy]-19-oxocard-20(22)-enolide; 3-Bromoacetoxystrophanthidin; 3-O-Bromoacetylstrophanthidin; Bromoacetic acid strophanthidin-3-yl ester
EINECS	Contact for details

Quality Control

Our Strophanthidin 3-Bromoacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP standards for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Assay	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.