Description

D-Ribose-1-3H is a high-purity, tritium-labeled derivative of the essential pentose sugar D-Ribose, identified by CAS No. 4933-79-3. This isotopically labeled compound is critical for advanced biochemical research, enabling precise metabolic pathway tracing and nucleotide synthesis studies. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers involved in radiometric assays, metabolic flux analysis, and the development of novel therapeutic agents.

Application

• Biochemical Research & Metabolic Tracer Studies: Used as a radioactive tracer to investigate the pentose phosphate pathway, nucleotide biosynthesis, and carbohydrate metabolism in cellular systems.
• Pharmaceutical R&D: Essential for studying the mechanism of action, absorption, and distribution of nucleoside-based drugs and other therapeutics that interact with ribose metabolism.
• Diagnostic Assay Development: Serves as a key reagent in the development and validation of sensitive radiometric assays and diagnostic kits.
• Enzymology Studies: Employed as a substrate for enzymes like ribokinase and phosphoribosyltransferases to study enzyme kinetics and inhibition.
• Nucleic Acid Research: Used in the synthesis of labeled nucleotides for probing RNA structure, function, and processing.

Basic Information

Product Name	D-Ribose-1-3H
CAS No.	4933-79-3
Molecular Formula	C5H93HO5
Molecular Weight	152.12 g/mol (unlabeled base)
Synonyms	1-3H-D-Ribose; [1-3H]Ribose; D-(-)-Ribose-1-t; Tritiated D-Ribose; Ribose (D-, [1-3H]); D-Ribose (1-tritiated); (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-1-3H
EINECS	225-565-6 (for unlabeled D-Ribose)

Quality Control

Our D-Ribose-1-3H is produced and handled under stringent quality control protocols to ensure batch-to-batch consistency and reliable specific activity. Each lot is analyzed for radiochemical purity and chemical purity using advanced chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing specific activity, purity, solvent composition, and analytical methods is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. Store in accordance with all local and national regulations for radioactive materials. Allow the product to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Clear, colorless solution
Specific Activity	Contact for details (Ci/mmol range)
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol:Water mixture (specified on COA)
Concentration	1 mCi/mL (typical, customized available)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.