Description

(7,7-Dimethyl-2-Oxo-Bicyclo[2.2.1]Hept-1-Yl)-Methanesulfonyl Chloride is a specialized organic intermediate featuring a reactive sulfonyl chloride group attached to a rigid norbornane-derived ketone framework. This compound matters for its role as a key building block in the synthesis of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily needed by R&D chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced material science applications.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, due to its unique bicyclic structure.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the norbornane skeleton can impart specific biological activity and environmental stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored thermal and mechanical properties.
• Organic Synthesis Reagent: Employed as a versatile sulfonylation agent to introduce the methanesulfonyl (mesyl) group into complex organic molecules under controlled conditions.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Catalyst Ligand Development: The rigid, three-dimensional structure makes it a candidate for developing novel chiral ligands in asymmetric catalysis.

Basic Information

Product Name	(7,7-Dimethyl-2-Oxo-Bicyclo[2.2.1]Hept-1-Yl)-Methanesulfonyl Chloride
CAS No.	4552-50-5
Molecular Formula	C10H15ClO3S
Molecular Weight	250.74 g/mol
Synonyms	1-(Methanesulfonyl)-7,7-dimethyl-2-norbornanone; 1-(Chlorosulfonyl)-7,7-dimethyl-2-norbornanone; 2-Norbornanone, 1-(methanesulfonyl)-, 7,7-dimethyl-; 7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonyl chloride; 1-Methanesulfonyl-7,7-dimethyl-2-norbornanone; (1R,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonyl chloride (for stereoisomer); 4552-50-5
EINECS	Contact for details

Quality Control

Our (7,7-Dimethyl-2-Oxo-Bicyclo[2.2.1]Hept-1-Yl)-Methanesulfonyl Chloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We can support development projects with custom purity grades and analytical method development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Single Maximum Impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.