Description

Diphenyleneiodonium Sulfate is a potent and selective inhibitor of flavoenzymes, including NADPH oxidase. This compound matters for researchers and manufacturers as it serves as a critical biochemical tool for studying reactive oxygen species (ROS) generation and related signaling pathways. It is needed by pharmaceutical R&D teams, academic research institutions, and specialty chemical producers focused on developing treatments for inflammation, cardiovascular diseases, and neurological disorders.

Application

• Biochemical Research: A key tool for inhibiting NADPH oxidase (NOX) isoforms to study the role of reactive oxygen species (ROS) in cellular signaling and disease models.
• Pharmaceutical Development: Used in preclinical research for investigating potential therapeutic interventions for conditions involving oxidative stress, such as inflammation, ischemia-reperfusion injury, and neurodegenerative diseases.
• Enzymology Studies: Employed as a selective inhibitor for various flavin-dependent enzymes to elucidate enzyme mechanisms and functions.
• Cell Biology: Utilized to probe mitochondrial function and apoptosis pathways where flavoenzyme activity is implicated.
• Reference Standard: Serves as a high-purity analytical standard for quality control in the production of research chemicals and assay kits.

Basic Information

Product Name	Diphenyleneiodonium Sulfate
CAS No.	4510-83-2
Molecular Formula	C12H8I2O4S
Molecular Weight	502.07 g/mol
Synonyms	Diphenyleneiodonium sulfate; DPI sulfate; 5H-Dibenzo[a,d]cyclohepten-5-one, 10,11-dihydro-, sulfate (2:1); Iodonium, diphenylene-, sulfate; NADPH oxidase inhibitor DPI; Flavoenzyme inhibitor DPI; Diphenyleneiodonium bis(sulfate)
EINECS	Contact for details

Quality Control

Our Diphenyleneiodonium Sulfate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.