Description

4-Epi-Anhydrotetracycline Hydrochloride is a chemically modified derivative of the tetracycline class of antibiotics. This compound is of significant value in pharmaceutical research and development, serving as a crucial intermediate or reference standard. It is primarily needed by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in antibiotic studies, method development, and quality control.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the identification and quantification of tetracycline-related compounds in analytical methods like HPLC and LC-MS.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR), degradation pathways, and metabolic profiles of tetracycline antibiotics.
• Impurity Profiling: Critical for the identification and control of process-related impurities and degradation products in the manufacture of tetracycline-based pharmaceuticals.
• Antibiotic Mechanism Studies: Utilized as a tool compound in microbiological and pharmacological research to understand bacterial resistance and antibiotic efficacy.
• Quality Control Laboratories: Serves as a key component in the validation of analytical procedures for antibiotic potency and purity testing in compliance with pharmacopeial guidelines.

Basic Information

Product Name	4-Epi-Anhydrotetracycline Hydrochloride
CAS No.	4465-65-0
Molecular Formula	C22H22N2O7 • HCl
Molecular Weight	462.88 g/mol (Free base: 426.42)
Synonyms	4-EATC HCl; 4-Epi-ATC Hydrochloride; 4-Epianhydrotetracycline HCl; (4S,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Hydrochloride; Anhydro-4-epitetracycline Hydrochloride; 4-Epi-ATC Monohydrochloride
EINECS	Contact for details

Quality Control

Our 4-Epi-Anhydrotetracycline Hydrochloride is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and consistency, meeting the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to yellowish-brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.